DMET Plus genotyping is a convenient approach to address unexplained PK variability.
The Affymetrix Drug Metabolizing Enzymes and Transporters (DMET) Plus Premier Pack offers the greatest representation of genetic diversity across known ADME markers.
It enables faster discovery and measurement of genetic variation associated with drug response than that provided using traditional non-multiplex methods. The polymorphisms represented on this array were chosen by virtue of their functional significance as documented in the scientific literature.
They have been publicly reviewed and prioritized by a panel of experts made up from both the pharmaceutical industry and academia. The Affymetrix DMET Plus Panel features markers in 100% of FDA-validated genes and covers 95% of the current ADME core markers as defined by the PharmaADME group.
DMET Plus genotypes 1,936 high-value drug metabolism and transporter markers in 231 genes. These markers have been evaluated across over 1,200 individuals from Caucasian, African, Asian and other populations.
When ordering IMGM’s Affymetrix DMET Plus service, you will profit from the following key benefits:
- Standardized ADME content
- High-value data with utmost biological relevance
- Streamlined workflow for cost effectiveness