IMGM Laboratories - your partner for genomic services - provides advanced genomic services tailored to the needs of customers coming from academia, pharma and biotech. (RNA services, DNA services, bioinformatics, consulting)
IMGM Laboratories - your partner for genomic services - (RNA services, DNA services, bioinformatics, consulting)
 

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DACH - ILAC-MRA: Accredited according to DIN EN ISO 17025, DIN EN ISO 15189
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Pharmacogenetics - Technology


At IMGM Laboratories, we offer a broad range of state-of-the-art technologies, analysis platforms and applications to serve your needs in pharmacogenetic testing.

Among these are:

  • Nucleic Acid Extraction (e.g. Qiagen, from blood, tissues, cells, buccal swabs, FFPE, etc.)

  • Nucleic Acid Quality Control (Agilent Bioanalyzer, NanoDrop)

  • Drug Metabolizing Enzymes and Transporter Analysis (Affymetrix DMET Plus Arrays)

  • SNP Analysis (Affymetrix SNP6.0 Arrays, TaqMan Allelic Discrimination Assays, Sequencing)

  • Next Generation Sequencing (Roche 454, Illumina, Life Technologies)

  • Sanger Sequencing (Life Technologies)

  • Quantitative and Qualitative Real-Time PCR (TaqMan Technology, Life Technologies)

  • Copy Number Variation Analysis (Agilent arrayCGH Arrays, TaqMan CNV Assays)

  • Gene Expression Analysis (Affymetrix and Agilent Microarrays, TaqMan Gene Expression Assays)

 

Affymetrix authorized DMET Plus array service

In its “Guideline on the use of pharmacogenetic methodologies in the pharmacokinetic evaluation of medicinal products” the EMA recommends carrying out candidate gene and targeted ADME1 SNP analyses (phenotype-genotype association studies) if important pharmacokinetic variability that is likely to influence the efficacy or safety of the drug in the variable subpopulation cannot be explained by other intrinsic or extrinsic factors. The EMA recommends more thorough investigations (e.g. genome-wide association studies) where appropriate to better understand the genetic contribution to variability in exposure.

 

IMGM Laboratories graphics - Affymetrix DMET Plus Array and Scanner
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DMET Plus genotyping is a convenient approach to address unexplained PK variability.

The Affymetrix Drug Metabolizing Enzymes and Transporters (DMET) Plus Premier Pack offers the greatest representation of genetic diversity across known ADME markers.

It enables faster discovery and measurement of genetic variation associated with drug response than that provided using traditional non-multiplex methods. The polymorphisms represented on this array were chosen by virtue of their functional significance as documented in the scientific literature.

They have been publicly reviewed and prioritized by a panel of experts made up from both the pharmaceutical industry and academia. The Affymetrix DMET Plus Panel features markers in 100% of FDA-validated genes and covers 95% of the current ADME core markers as defined by the PharmaADME group.

DMET Plus genotypes 1,936 high-value drug metabolism and transporter markers in 231 genes. These markers have been evaluated across over 1,200 individuals from Caucasian, African, Asian and other populations.


When ordering IMGM’s Affymetrix DMET Plus service, you will profit from the following key benefits:

  • Standardized ADME content

  • High-value data with utmost biological relevance

  • Streamlined workflow for cost effectiveness

 

 

IMGM is an Affymetrix Authorized Service Provider

 

IMGM Laboratories graphics - Affymetrix Authorized Service Provider Logo

Affymetrix appointed IMGM as Authorized Service Provider for the DMET Plus Array platform.

IMGM successfully passed Affymetrix's rigorous certification program and is now offering professional DMET Plus genotyping services for clinical and research studies.

For details on our Pharmacogenetics Services, please also review the IMGM Services Flyer - Pharmacogenetics.

These services are complemented with additional powerful Affymetrix GeneChip® based applications such as SNP genotyping (SNP 6.0 Array), gene expression analysis or copy number variation analysis.


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